Due to its unique GI life cycle and probiotic effects, B. coagulans has shown great potential in the treatment of various human diseases. For example, through direct regulation or indirect modulation via the host microbiota, B. coagulans plays an impressive role in eliminating infec- tions and attenuating both GI diseases and diseases in remote tissues. Furthermore, the ability of B. coagulans to maintain host microbiota homeostasis can also aid the digestion of daily meals and promote gut health. Therefore, beneficial effects of B. coagulans result from comprehensive and coordinated processes, involving the host micro- biome, metabolism and immune system. However, there are multiple B. coagulans strains with different host origins, and many of the probiotic functions of B. coagulans are strain-dependent. Therefore, it may be advantageous to combine different strains of B. coagulans to maximize their beneficial effects in the future.
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