The consumption of Bacillus coagulans GBI-30, 6086 (GanedenBC30) decreased the incidence rate of nasal congestion, bloody nasal mucus, itchy nose, hoarseness, and flatulencies, as well as the duration of hoarseness, headache, red eyes and fatigue in healthy school-aged children over a three-month period. These beneficial effects on upper- respiratory and gastrointestinal tract infection symptoms were asso- ciated with modulation of the immune system, since GanedenBC30 al- tered the serum levels of TNFα, CD163, G-CSF, ICAM-1, IL-6, IL-8, MCP- 2, RAGE, uPAR, and PF4. Therefore, these results suggest that GanedenBC30 may be used as a functional ingredient with positive immunomodulatory properties in children. This study contributes in the biomedical and clinical research with scientific information that sup- ports the beneficial effects of probiotics in the prevention and treatment of immune-related acute infections.
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